解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS)...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.12.082
更新日期:2013-12-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is involved in the pathogenesis of vascular diseases. Unlike activated protein C (APC), the activation of PAR-1 by thrombin is known to elicit proinflammatory responses. To determine whether the occupancy of EPCR by the Gla-domain of APC is responsible for the PAR-1-dependent antiinfl...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.11.056
更新日期:2013-11-01 00:00:00
abstract::Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.10.046
更新日期:2013-10-01 00:00:00
abstract::LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD). LRRK2 pathogenic-specific mutants induce neurotoxicity and shorten neurites. To elucidate the mechanism underlying LRRK2 expression, we constructed the LRRK2-prom...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.9.234
更新日期:2013-09-01 00:00:00
abstract::Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diver...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.8.191
更新日期:2013-08-01 00:00:00
abstract::Although there have been many studies of native Korean cattle, Hanwoo, there have been no selective sweep studies in these animals. This study was performed to characterize genetic variation and identify selective signatures. We sequenced the genomes of 12 cattle, and identified 15125420 SNPs, 1768114 INDELs, and 3445...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.7.211
更新日期:2013-07-01 00:00:00
abstract::Cecropin A and papiliocin are novel 37-residue cecropin-like antimicrobial peptides isolated from insect. We have confirmed that papiliocin possess high bacterial cell selectivity and has an α-helical structure from Lys(3) to Lys(21) and from Ala(25) to Val(35), linked by a hinge region. In this study, we demonstrated...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.5.252
更新日期:2013-05-01 00:00:00
abstract::To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour an...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.4.193
更新日期:2013-04-01 00:00:00
abstract::The AML1 gene is an essential transcription factor regulating the differentiation of hematopoietic stem cells into mature blood cells. Though at least 12 different alternatively spliced AML1 mRNAs are generated, three splice variants (AML1a, AML1b and AML1c) have been characterized. Here, using the reverse transcripti...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.3.171
更新日期:2013-03-01 00:00:00
abstract::Glucose effects on the vegetative growth of Dictyostelium discoideum Ax2 were studied by examining oxidative stress and tetrahydropteridine synthesis in cells cultured with different concentrations (0.5X, 7.7 g L(-1); 1X, 15.4 g L(-1); 2X, 30.8 g L(-1)) of glucose. The growth rate was optimal in 1X cells (cells grown ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.2.128
更新日期:2013-02-01 00:00:00
abstract::Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition,...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2013.46.1.078
更新日期:2013-01-01 00:00:00
abstract::p13 gene was first described in Leucania separata multinuclear polyhedrosis virus (Ls-p13) several years ago, but the function of P13 protein has not been experimentally investigated to date. In this article, we indicated that the expression of p13 from Heliothis armigera single nucleocapsid nucleopolyhedrovirus (Ha-p...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.12.058
更新日期:2012-12-01 00:00:00
abstract::Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2012.45.11.233
更新日期:2012-11-01 00:00:00
abstract::We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.10.044
更新日期:2012-10-01 00:00:00
abstract::Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death. Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negat...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2012.45.9.186
更新日期:2012-09-01 00:00:00
abstract::We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known function...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.8.040
更新日期:2012-08-01 00:00:00
abstract::L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. The present study was designed to investigate anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic f...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.6.276
更新日期:2012-06-01 00:00:00
abstract::Nicotinic acetylcholine receptors (nAChRs) are a diverse family of homo- or heteropentameric ligand-gated ion channels. Understanding the physiological role of each nAChR subtype and the key residues responsible for normal and pathological states is important. α-Conotoxin neuropeptides are highly selective probes capa...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.5.275
更新日期:2012-05-01 00:00:00
abstract::Viruses have evolved to manipulate the host cell machinery for virus propagation, in part by interfering with the host cellular signaling network. Molecular studies of individual pathways have uncovered many viral host-protein targets; however, it is difficult to predict how viral perturbations will affect the signali...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2012.45.4.213
更新日期:2012-04-01 00:00:00
abstract::Methylglyoxal (MG) was identified as an intermediate in non-enzymatic glycation and increased levels were reported in patients with diabetes. In this study, we evaluated the effects of MG on the modification of ferritin. When ferritin was incubated with MG, covalent crosslinking of the protein increased in a time- and...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2012.45.3.147
更新日期:2012-03-01 00:00:00
abstract::Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a compound derived from dopamine metabolism and is capable of causing dopaminergic neurodegeneration. Oxidative modification of neurofilament proteins has been implicated in the pathogenesis of neurodegenerative disorders. In this study, oxidative m...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2012.45.2.114
更新日期:2012-02-01 00:00:00
abstract::Alternative splicing generates several interleukin-6 (IL-6) isoforms; for them an antagonistic activity to the wild-type IL-6 has been proposed. In this study we quantified the relative abundance of IL-6 mRNA isoforms in a panel of mouse tissues and in C2C12 cells during myoblast differentiation or after treatment wit...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2012.45.1.32
更新日期:2012-01-01 00:00:00
abstract::Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep3B cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in bot...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.12.782
更新日期:2011-12-01 00:00:00
abstract::Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. I...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.11.735
更新日期:2011-11-01 00:00:00
abstract::In order to clarify the impact of Ca-binding sites (Ca1 and 2) on the conformational stability of neutral proteases (NPs), we have analyzed the thermal, pH and organic solvent stability of a NP variant, V189P/A195E/G203D/A268E (Q-mutant), from Salinovibrio proteolyticus. This mutant has shown to bind calcium more tigh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.10.665
更新日期:2011-10-01 00:00:00
abstract::Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver f...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.9.578
更新日期:2011-09-01 00:00:00
abstract::MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-me...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2011.44.8.547
更新日期:2011-08-01 00:00:00
abstract::Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpre...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.7.478
更新日期:2011-07-01 00:00:00
abstract::In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeL...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.6.381
更新日期:2011-06-01 00:00:00
abstract::The single-stranded DNA binding activity of the Escherichia coli RecA protein is crucial for homologous recombination to occur. This and other biochemical activities of ssDNA binding proteins may be affected by various factors. In this study, we analyzed the effect of CaCl(2), NaCl and NH(4)NO(3) salts in combination ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.5.341
更新日期:2011-05-01 00:00:00
abstract::In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specifi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.4.250
更新日期:2011-04-01 00:00:00
abstract::Insulin has antiapoptotic activity in various cell types. However, the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.3.205
更新日期:2011-03-01 00:00:00
abstract::Previous studies suggest that EphA7 plays a critical role in neural tube closure or cortical progenitor apoptosis. In this report, enhancer trap assay was used to modify various EphA7 BAC clones and screen a large genomic region spanning 570 kb downstream of the EphA7 gene. We found that the dorsal midline-specific Ep...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.2.113
更新日期:2011-02-01 00:00:00
abstract::Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). Several lines of evidence indicate that NOLC1 plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes. ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2011.44.1.70
更新日期:2011-01-01 00:00:00
abstract::Inter-cellular communication via diffusible small molecules is a defining character not only of multicellular forms of life but also of single-celled organisms. A large number of bacterial genes are regulated by the change of chemical milieu mediated by the local population density of its own species or others. The ce...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/BMBRep.2011.44.1.1
更新日期:2011-01-01 00:00:00
abstract::Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. β-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased i...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2010.43.12.824
更新日期:2010-12-01 00:00:00
abstract::Recent studies have reported that delayed-rectifier Kv channels regulate apoptosis in the nervous system. Herein, we investigated changes in the expression of the delayed-rectifier Kv channels Kv1.2, Kv2.1, and Kv3.1 after acute spinal cord injury (SCI) in rats. We performed RT-PCR analysis and found an increase in th...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2010.43.11.756
更新日期:2010-11-01 00:00:00
abstract::Kv4.2, a pore-forming α-subunit of voltage-gated A-type potassium channels, is expressed abundantly in the soma and dendrites of hippocampal neurons, and is responsible for somatodendritic I(A) current. Recent studies have suggested that changes in the surface levels of Kv4.2 potassium channels might be relevant to sy...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2010.43.10.677
更新日期:2010-10-01 00:00:00
abstract::Tetrahydrobiopterin (BH4) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine (DA) and serotonin (5-HT) as well as the release of glutamate (Glu). Deficiencies in BH4 levels and reduced activities of BH(4)-associated enzymes have been recently r...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/BMBRep.2010.43.9.593
更新日期:2010-09-01 00:00:00
abstract::In this study, we cloned the ERF-B3 subfamily transcription factor gene BnaERF-B3-hy15 from Brassica napus L. Huyou15. This 600 bp gene encodes a 199 amino acid classic ethylene responsive factor (ERF), which shown no binding or very weak binding GCC box-binding activity by the yeast one-hybrid assay. We used gene shu...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.8.567
更新日期:2010-08-01 00:00:00